The 12th Istanbul Biennial explores the rich relationship between art and politics, focusing on artworks that are both formally innovative and politically outspoken. It takes as its point of departure the work of the Cuban American artist Felix Gonzalez-Torres (1957–1996). Gonzalez-Torres was deeply attuned to both the personal and the political, and also rigorously attentive to the formal aspects of artistic production, integrating high modernist, minimal, and conceptual references with themes of everyday life. The biennial is composed of five group exhibitions and more than 50 solo presentations, all housed in a single venue, Antrepo 3 and 5. Each of the group shows—Untitled (Abstraction), “Untitled” (Ross), “Untitled” (Passport), Untitled (History), and “Untitled” (Death by Gun)—departs from a specific work by Gonzalez-Torres. These five works are reproduced in the Companion publication and function as thematic anchors for the biennial. Each group show features a large number of works occupying a single room, and is distinguished by its gray walls from the solo presentations. The solo presentations are linked to one or several subjects of the group exhibitions, and push the themes decidedly further. Visitors are encouraged to become active readers, not just silent recipients, of the artworks presented here. To paraphrase Gonzalez-Torres, the 12th Istanbul Biennial is untitled because meaning is always changing in time and space. In the spirit of Felix Gonzalez-Torres, who genuinely wanted to make this world a better place and believed that his art could be a catalyst for change, we welcome you to the 12th Istanbul Biennial.